The Role of Arachidonic Acid Metabolites (Endocannabinoids and Eicosanoids) in the Immune Processes: A Review
نویسندگان
چکیده
This review is devoted to the modern concepts of arachidonic acid metabolites – endocannabinoids and eicosanoids. We discussed their biosynthetic pathways, the interaction mechanisms and the role in the immune response. The results of our research on the endocannabinoid system and on the role of eicosanoids in the inflammatory process are given. We found that the synthetic ligands of cannabinoid receptors (WIN 55,212-2 and anandamide) dose-dependently inhibit the lipoxygenase pathway of the pro-inflammatory leukotriene B4 and the ability of the immune cells to express IL-2, IL-8, and TNF-α. The activities of the immune and the endocannabinoid systems have the reciprocal relationship which is characterized by the decrease in the СВ2 receptor expression and the activation of immune mechanisms. The obtained results on the role of endocannabinoid system in the regulation of the immune response are contributing to the understanding of molecular and cell mechanisms of inflammation development.
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